[ {
  "sequence" : 1,
  "text" : "Instil one drop in each eye twice daily",
  "timing" : {
    "repeat" : {
      "frequency" : 2,
      "period" : 1,
      "periodUnit" : "d"
    }
  },
  "route" : {
    "coding" : [ {
      "system" : "http://snomed.info/sct",
      "code" : "54485002",
      "display" : "Ophthalmic route (qualifier value)"
    } ]
  },
  "method" : {
    "coding" : [ {
      "system" : "http://snomed.info/sct",
      "code" : "421538008",
      "display" : "Instill - dosing instruction imperative (qualifier value)"
    } ]
  },
  "doseAndRate" : [ {
    "type" : {
      "coding" : [ {
        "system" : "http://terminology.hl7.org/CodeSystem/dose-rate-type",
        "code" : "ordered",
        "display" : "Ordered"
      } ]
    },
    "doseQuantity" : {
      "value" : 1,
      "unit" : "OPDROP",
      "system" : "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
      "code" : "OPDROP"
    }
  } ]
} ]